Research focus: Data mining approaches for on-line estimations of product quality and development of advanced control strategies for continuous bioprocesses.
Alexander Armstrong received his Bachelor’s Degree in Chemical Engineering with Honors (Cum Laude) at Rose-Hulman Institute of Technology (Indiana, USA). During this time, Alexander completed an internship under Prof. Brian Glennon in Dublin, Ireland, designing a pilot scale packed bed pressurized hot water extractor. Furthermore, under Dr. Irene Reizman, he completed bioreactor research simulating large scale oxygen gradients on a laboratory scale. He completed a Master’s Degree in Life Science and Technology (Specialization: Biochemical Engineering) at TU Delft in the Netherlands. There he participated in the 2018 iGEM team as the Modelling Manager, which developed a targeted sequencing method to combat gene doping. The team went on to win Best New Application and Best Product Design in the Boston Giant Jamboree, as well as being nominated for five other awards. Alexander completed his master thesis in Dr. Stan Brouns’ laboratory focused on comparing the target search dynamics of the CRISPR-Cas I-F and I-E immune systems in vivo. The thesis coupled microbiology, microscopy, and modelling techniques to visualization CRISPR proteins in cells, determining their diffusion and kinetic parameters. During July 2019, Alexander participated in the TU Delft sponsored biotech Mastertrip to Singapore and Malaysia, focused on meeting representatives from companies and universities in the region. Following his Master’s Degree, Alexander was awarded with a Marie Skolodowska-Curie actions PhD fellowship, in the framework of the CODOBIO project, under the supervision of Prof. Suzanne Farid and Dr. Stephen Goldrick (University College London, England). The primary research focus is the development of multivariate data analysis (MVDA) models to enable on-line predictions of product quality and identify optimum process operating conditions for continuous chromatography and other downstream process operations.