I have a master of science (MSc) degree in chemical engineering in the field of biotechnology, from Amirkabir University of Technology (AUT). Also, I also have few years working experience in a biopharmaceutical company in R&D department with main focus on downstream processing. In 2019 I started my project in CODOBIO. The project title is “Residence time distribution (RTD): effect on start-up and shut-down for product collection”. As a part of CODOBIO project, this project consists of the PhD program in BioProcess Engineering in University of Natural Resources and Life Sciences, Vienna (Universität für Bodenkultur Wien, BOKU).
The goal of this research project is establishing a model for the residence time distribution of a complete downstream process for understanding the start-up and shut-down times as well as where to cut for project collection for continuous processes. This is crucial for understanding and managing possible process disturbances as well as the start and end of the process. To achieve a complete model for the whole downstream chain, each unit operation will be modelled individually before combining all models into a complete process model. The unit operations in this research project will be based on the established scheme for antibody purification.
The major accomplishments expected in this project are:
• Establishing a program that can handle multiple residence time distributions and the combination into a process scheme with dynamic sequence
• Establish the model descriptions for each individual unit operation in the process chain of a monoclonal antibody purification
• Verifying the model assumptions in terms residence time distribution experimentally for each unit operation.