Results

Publications

Pons Royo, M.D.C., De Santis, T., Komuczki, D., Satzer, P., Jungbauer, A.
Precipitation of antibodies by feeding of solid polyethylene glycol, Separation and Purification Technology 304, 122373, 2023
10.1016/j.seppur.2022.122373

Ronin, L,. Dotelli, G.
Life Cycle Assessment Overview on Polyhydroxyalkanoates, Innovazione e circolarità, Il contributo del Life Cycle Thinking nel Green Deal per la neutralità climatica. Italia: Associazione Rete Italiana LCA, pp. 358–365, 2022.

São Pedro, M.N., Santos, M.S., Eppink, M.H.M., Ottens, M.
Design of a microfluidic mixer channel: First steps into creating a fluorescent dye-based biosensor for mAb aggregate detection, Biotechnology Journal, 2022
https://doi.org/10.1002/biot.202200332

Eslami, T., Steinberger, M., Csizmazia, C., Jungbauer, A., Lingg, N.
Online optimization of dynamic binding capacity and productivity by model predictive control, Journal of Chromatography A, 1680, 2022
https://doi.org/10.1016/j.chroma.2022.463420

Eslami T., Jakob, L.A., Satzer P., Ebner G., Jungbauer A., Lingg N.
Productivity for free: Residence time gradients during loading increase dynamic binding capacity and productivity, Separation and Purification Technology, 281, 2022
https://doi.org/10.1016/j.seppur.2021.119985

Guo, Y., Ali, W., Schneider, A., Salma, A., Mayer-Gall, T., Gutmann, J.S., Fernandez Lahore, H.M.
Megaporous monolithic adsorbents for bioproduct recovery as prepared on the basis of nonwoven fabrics, Electrophoresis, 43 (13-14), 2022
https://doi.org/10.1002/elps.202100220

Pons Royo, M.D.C., Montes-Serrano, I., Valery, E., Jungbauer, A., Satzer, P.
Milliscale reactors for integration of continuous precipitation and filtration, Journal of Chemical Technology and Biotechnology, 2022
https://doi.org/10.1002/jctb.7187

Pons Royo, M.d.C., Beulay, J.-L., Valery, E., Jungbauer, A., Satzer, P.
Design of millidevices to expedite apparent solubility measurements Reaction, Chemistry and Engineering, 2022
https://doi.org/10.1039/d2re00022a

Pons Royo, M.d.C., Beulay, J.-L., Valery, E., Jungbauer, A., Satzer, P.
Mode and dosage time in polyethylene glycol precipitation process influences protein precipitate size and filterability, Process Biochemistry, Volume 114, 2022
https://doi.org/10.1016/j.procbio.2022.01.017

Lali N., Satzer P., Jungbauer A.
Residence time distribution in counter-current protein A affinity chromatography using an inert tracer, Journal of Chromatography A, Volume 1683, 2022
https://doi.org/10.1016/j.chroma.2022.463530

Silva, T.C., Eppink, M., Ottens, M.
Small, smaller, smallest: Miniaturization of chromatographic process development, Journal of Chromatography A, 1681, 2022
https://doi.org/10.1016/j.chroma.2022.463451

J. Scheffel, M. Isaksson, J. Gomis-Fons, H. Schwarz, N. Andersson, B. Norén, A. Solbrand, V. Chotteau, S. Hober, B. Nilsson
Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand, Journal of Chromatography A, 1664, 2022
https://doi.org/10.1016/j.chroma.2022.462806

I. Montes-Serrano, P. Satzer, A. Jungbauer, A. Dürauer
Characterization of hydrodynamics and volumetric power input in microtiter plates for the scale-up of downstream operations (2022), Biotechnology and Bioengineering, 119 (2), 2022
https://doi.org/10.1002/bit.27983

A. Javidanbardan, V. Chu, J.P. Conde, A.M. Azevedo
Microchromatography integrated with impedance sensor for bioprocess optimization: Experimental and numerical study of column efficiency for evaluation of scalability
Journal of Chromatography A, 1661, 2022
https://doi.org/10.1016/j.chroma.2021.462678

H. Schwarz, J. Gomis-Fons, M. Isaksson, J. Scheffel, N. Andersson, A. Andersson, A. Castan, A. Solbrand, S. Hober, B. Nilsson, V. Chotteau
Integrated continuous biomanufacturing on pilot scale for acid-sensitive monoclonal antibodies
Biotechnology and Bioengineering, 2022
https://doi.org/10.1002/bit.28120

A. Javidanbardan, A.M. Azevedo, V. Chu, J.P. Conde
A systematic approach for developing 3d high-quality pdms microfluidic chips based on micromilling technology, Micromachines, 13 (1), 2022
https://doi.org/10.3390/mi13010006

Lali N., Jungbauer A., Satzer P.
Traceability of products and guide for batch definition in integrated continuous biomanufacturing, Journal of Chemical Technology and Biotechnology, 2021
https://doi.org/10.1002/jctb.6953

Armstrong, K. Horry, T. Cui, M. Hulley, R. Turner, S. S. Farid, S. Goldrick, D. G. Bracewell
Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products, Journal of Chromatography A, Volume 1639, 2021, 461914,
https://doi.org/10.1016/j.chroma.2021.461914

N. São Pedro, T.C. Silva, P. Rohan, M. Ottens
White paper on high-throughput process development for integrated continuous biomanufacturing Biotechnology and Bioengineering, 2021
https://doi.org/10.1002/bit.27757

T.C. Silva, M. Eppink, M. Ottens
Automation and miniaturization: enabling tools for fast, high-throughput process development in integrated continuous biomanufacturing, Journal of Chemical Technology and Biotechnology, 2021
https://doi.org/10.1002/jctb.6792

Yelemane, M. Kangwa, R.N. Dsouza, M. Fernández-Lahore
Surface energetics to assess influence of biomass-type and biomass–adsorbent interactions in expanded beds, Bioresources and Bioprocessing, 8 (1), art. no. 29, 2021
https://doi.org/10.1186/s40643-021-00382-6

M.N. São Pedro, M.E. Klijn, M.H.M. Eppink, M. Ottens
Process analytical technique (PAT) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing
Journal of Chemical Technology and Biotechnology, 2021
https://doi.org/10.1002/jctb.6920

Schneider A., Herlevi L.-M., Guo,Y., Fernández Lahore, H.M.
Perspectives on adsorption technology as an effective strategy for continuous downstream bioprocessing, Journal of Chemical Technology and Biotechnology, 2021
https://doi.org/10.1002/jctb.6923

Medeiros Garcia Alcântara, F. Distante, G. Storti, D. Moscatelli, M. Morbidelli, M. Sponchioni
Current trends in the production of biodegradable bioplastics: The case of polyhydroxyalkanoates, Biotechnology Advances, Volume 42, 2020, 107582,
https://doi.org/10.1016/j.biotechadv.2020.107582

Movies

CODOBIO Expert Interviews

The ICB V conference was also used to talk to experts and pioneers from global biopharmaceutical companies active in the field of continuous downstream processing about their view on the contribution of well-trained young scientists to the advancement of the field. You can watch here the interviews that CODOBIO coordinator Alois Jungbauer held with three leading experts: Kevin Brower (Sanofi), Chetan Goudar (Amgen) and Konstantin Konstantinov (Codiak Biosciences). A longer version also contains their views on continuous bioprocessing in general.

European Researchers Night 2020

Ignacio Monte-Serrano works in the MSCA-ITN project Codobio! He tells us about his work as a PhD student.

Blog Articles

Some CODOBIO fellows have presented their work in blog articles on the science blog hosted by acib

L. Ronin, Politecnico di Milano
Continuous downstream production of polyhydroxyalkanoates, a family of biodegradable plastics

M. Isaksson, Lund University
“Smart-factories” for continuous downstream processing of antibodies